毕业院校

北京师范大学

学    位

博士

所属系

三亚南繁研究院

职    务

无

专业技术

职务

副研究员

导师类别

博士生、硕士生导师

从事专业

生物信息学，植物病理学

电子邮箱

linrm2010@163.com, linrunmao@hainanu.edu.cn

办公地址

崖州、海口

个人简介

本人主要致力于基因组学和计算生物学、病原与寄主互作、以及生物防治研究，以共同一作或共同通讯在Nature Communications，PLOS Pathogens，Communications Biology，Applied Microbiology and Biotechnology等期刊发表相关研究成果。

教育经历

2007年获北京交通大学理学学士学位，2015年获中国农业科学院研究生院农学硕士学位，2018年获北京师范大学理学博士学位。

工作经历

2022年至今，海南大学；曾在华大基因、四川农业大学水稻研究所生物技术课题组和中国农业科学院蔬菜花卉研究所工作。

研究方向

为了探索微生物如何适应植物寄主，并激活寄主免疫反应，以及微生物与寄主的协同演化，开展以下研究：（1）微生物基因组；（2）单细胞转录组；（3）微生物与寄主互作；（4）生物防治。

研究成果

一、科研项目：

1. 国家自然科学基金委员会，地区科学基金项目，立枯丝核菌效应蛋白Rspi2抑制水稻防御反应的分子机制，32360641，2024-01至2027-12，在研，主持。

2. 海南省自然科学基金面上项目，基于单细胞转录组分析研究哈茨木霉T069与番茄根部的互作机制，823MS034，2023-03至2026-02，在研，主持。

3. 海南大学科研启动基金项目，木霉生防菌促进番茄根系生长的分子机制，KYQD(ZR)23023，2022-06至2027-06，在研，主持。

4. 国家自然科学基金委员会，国际（地区）合作与交流项目，植物三萜代谢多样性的催化机制及功能研究，31920103003，2020-01至2024-12，结题，参加。

5. 中央级公益性科研院所基本科研业务费专项，叶片单细胞图谱及其多样性的解析，IVF-BRF2019020，结题，主持。

二、学术论文（†，共同第一作者；*，共同通讯作者）：

1. Zhao Z, Zhang H, Wang J, Luo N, Li H*, Lin R*, Xie B*. Comparative genomics of different haplotypes in Ditylenchus destructor provides insights into their host preferences. Communications Biology. Accepted.

2. Cui H^†, Zhang L^†, Liu T*, Lin R*. WMAF: One novel method for whole mitogenome alignment in fungi and its application in phylogenetic analysis. Fungal Genetics and Biology. 2026,183:104068.

3. Zhang L^†, Cui H^†, Yu S, Yan R, Wang B, Lin R*, Liu T*. TGP-WEB: A server for automatic gene prediction of Trichoderma genomes. Phytopathology. 2026. Online. doi: 10.1094/PHYTO-12-25-0399-R.

4. Wang B, Tan S, Wu M, Feng Y, Yan W, Yun Q, Ji X, Lin R*, Zhao Z*. Effects of two Bacillus velezensis strains isolated from different sources on the growth of Capsicum annum. Frontiers in Microbiology. 2024,15:1504660.

5. Wang X, Wang Z, Yang F, Lin R*, Liu T*. Assembly, annotation, and comparative analysis of mitochondrial genomes in Trichoderma. International Journal of Molecular Sciences. 2024,25(22):12140.

6. Zhang D^†, Lin R^†, Yamamoto N^†, Wang Z, Lin H, Okada K, Liu Y, Xiang X, Zheng T, Zheng H, Yi X, Noutoshi Y, Zheng A*. Mitochondrial-targeting effector RsIA_CtaG/Cox11 in Rhizoctonia solani AG-1 IA has two functions: plant immunity suppression and cell death induction mediated by a rice cytochrome c oxidase subunit. Molecular Plant Pathology. 2024,25(1):e13397.

7. Zhang C^†, Lin R^†, Hou J, Khan R, Li X, Wei H, Chen J, Wang R, Zhang J, Liu T*. The unique sugar conversion and complex CAZyme system of Trichoderma brev T069 during solid-state fermentation of cassava peel. Industrial Crops and Products. 2023, 193:116263.

8. Zhang M^†, Cheng X^†, Lin R^†, Xie B, Nauen R, Rondon SI, Zavala JA, Palli SR, Li S, Xiong X, Zhou W*, Gao Y*. Chromosomal-level genome assembly of potato tuberworm, Phthorimaea operculella: a pest of solanaceous crops. Scientific Data. 2022,9(1):748.

9. Zhang X^†, Lin R^†, Ling J, Wang Y, Qin F, Lu J, Sun X, Zou M, Qi J, Xie B*, Cheng X*. Roles of species-specific legumains in pathogenicity of the pinewood nematode Bursaphelenchus xylophilus. International Journal of Molecular Sciences. 2022,23(18):10437.

10. Wu J^†, Liang J^†, Lin R^†, Cai X, Zhang L, Guo X, Wang T, Chen H, Wang X*. Investigation of Brassica and its relative genomes in the post-genomics era. Horticulture Research. 2022,9:uhac182.

11. Tian X^†, Sun T^†, Lin R^†, Liu R, Yang Y, Xie B*, Mao Z*. Genome sequence resource of Sarocladium terricola TR, an endophytic fungus as a potential biocontrol agent against Meloidogyne incognita. Molecular Plant-Microbe Interactions. 2022,35(6):505-508.

12. Guo X^†, Liang J^†, Lin R^†, Zhang L, Wu J, Wang X*. Series-spatial transcriptome profiling of leafy head reveals the key transition leaves for head formation in Chinese cabbage. Frontiers in Plant Science. 2022,12:787826.

13. Lin R^†, Xia Y^†, Liu Y^†, Zhang D^†, Xiang X, Niu X, Jiang L, Wang X, Zheng A*. Comparative mitogenomic analysis and the evolution of Rhizoctonia solani anastomosis groups. Frontiers in Microbiology. 2021,12:707281.

14. Yamamoto N^†, Wang Y^†, Lin R^†, Liang Y, Liu Y, Zhu J, Wang L, Wang S, Liu H, Deng Q, Li S, Li P, Zheng A*. Integrative transcriptome analysis discloses the molecular basis of a heterogeneous fungal phytopathogen complex, Rhizoctonia solani AG-1 subgroups. Scientific Reports. 2019,9(1):19626.

15. Lin R^†, Zhang X^†, Xin B, Zou M, Gao Y, Qin F, Hu Q, Xie B*, Cheng X*. Genome sequence of Isaria javanica and comparative genome analysis insights into family S53 peptidase evolution in fungal entomopathogens. Applied Microbiology and Biotechnology. 2019,103(17):7111-7128.

16. Lin R^†, Qin F^†, Shen B^†, Shi Q, Liu C, Zhang X, Jiao Y, Lu J, Gao Y, Suarez-Fernandez M, Lopez-Moya F, Lopez-Llorca LV, Wang G, Mao Z, Ling J, Yang Y, Cheng X*, Xie B*. Genome and secretome analysis of Pochonia chlamydosporia provide new insight into egg-parasitic mechanisms. Scientific Reports. 2018,8(1):1123.

17. Lin R^†, He L^†, He J, Qin P, Wang Y, Deng Q, Yang X, Li S, Wang S, Wang W, Liu H, Li P*, Zheng A*. Comprehensive analysis of microRNA-Seq and target mRNAs of rice sheath blight pathogen provides new insights into pathogenic regulatory mechanisms. DNA Research. 2016,23(5):415-425.

18. Wang G^†, Liu Z^†, Lin R^†, Li E, Mao Z, Ling J, Yang Y, Yin WB*, Xie B*. Biosynthesis of antibiotic leucinostatins in bio-control fungus Purpureocillium lilacinum and their inhibition on Phytophthora revealed by genome mining. PLOS Pathogens. 2016,12(7):e1005685.

19. Lin R^†, Liu C^†, Shen B, Bai M, Ling J, Chen G, Mao Z, Cheng X*, Xie B*. Analysis of the complete mitochondrial genome of Pochonia chlamydosporia suggests a close relationship to the invertebrate-pathogenic fungi in Hypocreales. BMC Microbiology. 2015,15:5.

20. Lei D^†, Lin R^†, Yin C^†, Li P*, Zheng A*. Global protein-protein interaction network of rice sheath blight pathogen. Journal of Proteome Research. 2014,13(7):3277-3293.

21. Zheng A^†,*, Lin R^†, Zhang D, Qin P, Xu L, Ai P, Ding L, Wang Y, Chen Y, Liu Y, Sun Z, Feng H, Liang X, Fu R, Tang C, Li Q, Zhang J, Xie Z, Deng Q, Li S, Wang S, Zhu J, Wang L, Liu H, Li P*. The evolution and pathogenic mechanisms of the rice sheath blight pathogen. Nature Communications. 2013,4:1424.

其他合作论文（参与）：

1. Xue M, Wang R, Hou J, Khan RAA, Chen J, Lin R, Wang L, Zhao H, Ahammed GJ, Liu T. A Trichoderma microRNA-like RNA suppresses a chitinase gene in Solanum lycopersicum to escape host immunity during early root colonization. Plant Physiology. 2025,199(2):kiaf413.

2. Liu Q†, Zuo SM†, Peng S, Zhang H, Peng Y, Li W, Xiong Y, Lin R, Feng Z, Li H, Yang J, Wang GL, Kang H*. Development of machine learning methods for accurate prediction of plant disease resistance. Engineering. 2024,40:100–110.

3. Sun X, Liao J, Lu J, Lin R, Zou M, Xie B*, Cheng X*. Parasitism of Hirsutella rhossiliensis on different nematodes and its endophytism promoting plant growth and resistance against root-knot nematodes. Journal of Fungi. 2024,10(1):68.

4. Guo X, Liang J, Lin R, Zhang L, Zhang Z, Wu J*, Wang X*. Single-cell transcriptome reveals differentiation between adaxial and abaxial mesophyll cells in Brassica rapa. Plant Biotechnology Journal. 2022,20(12):2233-2235.

5. Chen H, Wang T, He X, Cai X, Lin R, Liang J, Wu J, King G, Wang X*. BRAD V3.0: an upgraded Brassicaceae database. Nucleic Acids Research. 2022,50(D1):D1432-D1441.

6. Qin F†, Li Y†, Lin R, Zhang X, Mao Z, Ling J, Yang Y, Zhuang X, Du S, Cheng X*, Xie B*. Antibacterial radicicol analogues from Pochonia chlamydosporia and their biosynthetic gene cluster. Journal of Agricultural and Food Chemistry. 2019,67(26):7266-7273.

7. Kang H†, Zhu D†, Lin R, Opiyo SO, Jiang N, Shiu SH, Wang GL*. A novel method for identifying polymorphic transposable elements via scanning of high-throughput short reads. DNA Research. 2016,23(3):241-251.

8. Li R†, Fan W†, Tian G†, Zhu H†, He L†, Cai J†, Huang Q, Cai Q, …, Ni P, Lin R, …, Olson M, Zhang X, Li S, Yang H, Wang J*, Wang J*. The sequence and de novo assembly of the giant panda genome. Nature. 2010,463(7279):311-317.

三、专著：

1. Lin R, Cheng X*, Xie B*. Comparative analysis of Pochonia chlamydosporia mitogenome reveals dynamic mitochondrial evolution of the nematophagous fungi in Hypocreales. In: Perspectives in sustainable nematode management through Pochonia chlamydosporia applications for root and rhizosphere health. (eds Manzanilla-López RH, Lopez-Llorca LV). Springer. 2017, pp:183–195, Chapter 9.

四、授权专利：

1. 王晓武; 林润茂; 武剑; 梁建丽; 郭新磊. 基于单细胞转录组测序数据的细胞聚类方法, 2022-02-08, 中国, ZL 2021 1 0983443.7.

五、软件著作权：

1. 崔厚松; 张丽; 林润茂; 刘铜. 真菌线粒体全基因组序列比对方法, 2025-11-26, 2025SR2278133.

2. 林润茂; 刘铜; 王晓婷; 杨繁兴; 王芷茵. 真菌线粒体基因组分析软件, 2023-09-26，2023SR1163714.

3. 林润茂; 王晓武; 武剑; 梁建丽; 郭新磊. CADEG：全基因组差异表达基因的比较分析软件, 2020-03-19, 2020SR0277868.

获得荣誉

海南自由贸易港E类人才，三亚崖州湾科技城E类人才，全国大学生生命科学竞赛（2025，科学探究类）海南赛区三等奖（指导教师）

教学和研究生培养

一、讲授课程：

1. 本科生课程《生物信息学》、《生物信息学实验》、《农业物联网》等。

2. 研究生课程《资源利用与植物保护进展》、《植物保护学前沿》、《植物免疫学》等。

二、参与指导和培养学生：

1. 在读博士研究生1名，在读硕士研究生5名；在读本科生4名。

2. 已毕业硕士研究生2名。

社会兼职

担任Bioinformatics Advances、Frontiers in Microbiology、Horticultural Plant Journal、Plant Disease、Wellcome Open Research等期刊审稿人。

招生专业

生物信息学、植物保护学、种子科学与工程、生物学、生态学、数学、计算机科学等相关专业。