一、基本情况

职称：教授

邮箱：evangelos.tatsis@hainanu.edu.cn

研究领域：植物次生代谢

招生专业：作物遗传育种、农业生物技术

教育背景：

1996/10 – 2001/04  希腊约阿尼纳大学 学士

2001/10 – 2006/04  希腊约阿尼纳大学  博士

工作简历：

2025/01 –至今         海南大学南繁学院，教授

2017/09 – 2024/12   中国科学院分子植物科学卓越创新中心  研究员

2013/09 – 2017/08   英国约翰·英尼斯中心 博士后

2008/04 – 2012/12   德国马克斯.普朗克化学生态学研究所 博士后

荣誉与奖项

2022/01 – 2023/12   国家自然科学基金委员会（NSFC）国际优秀青年科学家  

2019/12 – 2023/05   英国皇家学会牛顿高级学者基金  

2008/04 – 2010/04   玛丽·居里学者基金  

二、科研概况

科研项目：

 1. 国家自然科学基金外国学者研究基金项目，32150610477，Novel anti-cancer alkaloids form Alstonia trees ，2022.1-2023.12，80万，主持；

 2. 科技部高端外国专家引进计划项目，E12GA112C1,贯叶金丝桃素生物合成途径的解析, 2021.1-2022.12，40万,主持

 3. 英国皇家学会牛顿高级学者基金项目，NAFR2192001,Scutellaria Anti-Cancer Metabolites-SCAM，2019.1-2021.12，70万，主持

 4. 科技部国家外国专家项目，E25GA212C1,黄芩属植物抗癌代谢产物的研究,2019.1-2019.12，50.93万,主持

 5. 中国科学院先导专项（B）类项目，XDB27020204，基于基因组发现新抗微生物的植物杂萜类化合物的合成代谢研究，2018.6-2023.5，225万，主持

代表性成果：

1. Lin, Ruoxi, Haixiu Li, Yiren Xiao, Zhuo Wang, Licheng Liu, Gerhard Saalbach, Carlo Martins, Matthew Furry, Christopher D. Vanderwal, Cathie Martin, Evangelos C. Tatsis*. 2025. “Three cytochrome P450 enzymes consecutively catalyze the biosynthesis of furanoclerodane precursors in Salvia species” Plant Communication – accepted (IF: 9.4)

2. Wu, Song, Evangelos C. Tatsis*. 2024. “Specialized metabolism in St John’s wort” Curr Opin in Plant Bio, 82, 102625 (IF: 8.3)

3. Wu, Wenjuan, Yuxin Zhuang, Dasong Chen, Yiting Ruan, Fuyu Li, Kirsty Jackson, Cheng-Wu Liu, Alison East, Jiangqi Wen, Evangelos Tatsis, Philip S. Poole, Ping Xu*, and Jeremy D. Murray*. 2024. 'Methylated chalcones are required for rhizobial nod gene induction in the Medicago truncatula rhizosphere', New Phytologist, 242: 2195-206. (IF: 8.3)

4. Wu, Song, Ana Luisa Malaco Morotti, Jun Yang, Ertao Wang, and Evangelos C. Tatsis*. 2024. 'Single cell RNA sequencing facilitates the elucidation of the complete biosynthesis of the antidepressant hyperforin in St. John’s wort', Mol Plant, 17: 1439-1457. (IF: 17.1)

5. Li, H., S. Wu, R. Lin, Y. Xiao, A. L. Malaco Morotti, Y. Wang, M. Galilee, H. Qin, T. Huang, Y. Zhao, X. Zhou, J. Yang, Q. Zhao, A. K. Kanellis, C. Martin, and E. C. Tatsis*. 2023. 'The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae', Mol Plant, 16: 549-70. (IF: 17.1)

6. Wang, Ya, Ana Luisa Malaco Morotti, Yiren Xiao, Zhuo Wang, Song Wu, Jianghua Chen, and Evangelos C. Tatsis*. 2022. 'Decoding the Cytochrome P450 Catalytic Activity in Divergence of Benzophenone and Xanthone Biosynthetic Pathways', ACS Catalysis, 12: 13630-37. (IF: 11.7)

7. Langley, Chloe, Evangelos Tatsis, Benke Hong, Yoko Nakamura, Christian Paetz, Clare E. M. Stevenson, Jerome Basquin, David M. Lawson, Lorenzo Caputi, and Sarah E. O'Connor*. 2022. 'Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism', Angewandte Chemie International Edition, 61: e202210934. (IF: 16.1)

8. Wang, Z., Y. Xiao, S. Wu, J. Chen, A. Li, and E. C. Tatsis*. 2022. 'Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis', Chem Sci, 13: 12389-95. (IF: 7.6)

9. Tomlinson, Matthew L., Man Zhao, Elaine J. Barclay, Jie Li, Haixiu Li, Juri Felix, Lionel Hill, Gerhard Saalbach, Martin Rejzek, Dongfeng Yang, Qing Zhao, Paul Kroon, Wei Wang, Yongping Bao, Melanie-Jayne R. Howes, Evangelos C. Tatsis*, and Cathie Martin*. 2022. 'Diterpenoids from Scutellaria barbata induce tumour-selective cytotoxicity by taking the brakes off apoptosis', Medicinal Plant Biology, 1: 1-16.

10. Wu, Song, Ana Luisa Malaco Morotti, Shanshan Wang, Ya Wang, Xiaoyan Xu, Jianghua Chen, Guodong Wang, and Evangelos C. Tatsis*. 2022. 'Convergent gene clusters underpin hyperforin biosynthesis in St John's wort', New Phytologist, 235: 646-61. (IF: 8.3)

11. Tatsis, E. C., I. Carqueijeiro, T. Dugé de Bernonville, J. Franke, T. T. Dang, A. Oudin, A. Lanoue, F. Lafontaine, A. K. Stavrinides, M. Clastre, V. Courdavault, and S. E. O'Connor*. 2017. 'A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate', Nat Commun, 8: 316. (IF: 14.7)

12. Stavrinides, A.^#, E. C. Tatsis^#, L. Caputi, E. Foureau, C. E. Stevenson, D. M. Lawson, V. Courdavault, and S. E. O'Connor*. 2016. 'Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity', Nat Commun, 7: 12116. (IF: 14.7)