团队名称：作物代谢多样性与环境适应性研究创新团队

团队负责人：

王守创，海南大学南繁学院教授，博士生导师。海南省C类人才，入选中国科协青年人才托举工程、海南省“515人才工程”、“第六届全国专业技术人才先进集体”，获首届“海南大学青年五四奖章”。长期从事重要作物代谢生物学及营养品质改良研究，利用多组学整合分析系统揭示作物代谢组的遗传和生化基础，为作物重要性状改良提供了代谢组学辅助育种的新手段。部分研究成果入选 “十三五”期间农业科技标志性成果和“2019中国农业科学重大进展”，相关研究成果以第一或通讯作者（含共同）在Cell、Mol Plant、Genome Biol、Plant Biotechnol J、Trends in Genetics、Curr Opin Plant Biol、New Phyto等国际主流期刊发表SCI论文25篇，论文总他引2400多次，授权国家发明专利9项。主持主持国家自然科学基金、科技部重点研发计划、中国科协和海南省人才科技项目等10项。兼任热带生物学报编委、Frontiers in Plant Science和Beverage Plant Research编委、热带作物学报青年编委。

团队研究方向：

本团队长期以来一直致力于作物代谢多样性与环境适应性的互作机理解析研究。以番茄和玉米等模式作物为研究对象，以代谢组学为切入点，综合运用生物信息学、基因组学、生物化学、分子生物学、细胞生物学等多种手段，致力于代谢组学检测新技术开发，以及作物代谢多样性与环境适应性研究。

团队代表性成果：

（一）论文

(^+/*Co-First author or Co-Correspondence author:)

1. Zhu G#, Wang S#, Huang Z, Zhang S, Liao Q, Zhang C, Lin T, Qin M, Peng M, Yang C, Cao X, Han X, Wang X, Knaap E, Zhang Z, Cui X, Klee K, Fernie AR, Luo J*, Huang S*. Rewiring of the fruit metabolome in tomato breeding. Cell 2018, 172, 249-261.

2. Yang Jie, Zhang Z H, Li X G, Guo L C, Li C, Lai J, Han Y G, Ye W Z, Miao Y Y, Deng M, Cao P, Zhang Y R, Ding X Y, Zhang J N, Yang Jun, Wang S *. A gene cluster for polyamine transport and modification improves salt tolerance in tomato. The Plant Journal 2024. Oct 14. doi: 10.1111/tpj.17074.

3. Zhang F, Yang C K, Guo H, Li Y F, Shen S Q, Zhou Q Q, Li C, Wang C, Zhai T, Qu L H, Zhang C, Liu X Q, Luo J, Chen W, Wang S, Yang J*, Yu C* & Liu Y Y *. Dissecting the genetic basis of UV-B responsive metabolites in rice. Genome biology 2024, 25(1).

4. Zhang Z, Ye W, Li C, Zhou H, Wang C, Liu P, Zhou B, Zhao H, Wang S, Yang J *. Volatilomics-Based Discovery of Key Volatiles Affecting Flavor Quality in Tomato. Foods, 2024, 13(6).

5. Guo Z L#, Wang S C#, Zhang F, Xiang D H, Yang J, Li D, Bai B W, Dai M Q, Luo J*, Xiong L Z*. Common and specific genetic basis of metabolite-mediated drought responses in rice. Stress Biology 2024, 4(1).

6. Cao P #, Yang Jun #,*, Xia L H, Zhang Z H, Wu Z Y, Hao Y C, Liu P H, Wang C, Li C, Yang Jie, Lai J, Li X G, Deng M, Wang S C*. Two gene clusters and their positive regulator SlMYB13 that have undergone domestication-associated negative selection control phenolamide accumulation and drought tolerance in tomato. Molecular Plant, 2024. Apr 1;17(4):579-597. doi: 10.1016/

7. Yang J, Chen R D, Wang C, Li C, Ye W Z, Zhang Z H, Wang S C*. A widely targeted metabolite modificomics strategy for modified metabolites identification in tomato. Journal of Integrative Plant Biology, 2024. Apr;66(4):810-823. doi: 10.1111/

8. Wang S C#, Shen S Q#, Wang C#, Wang X, Yang C K, Zhou S, Zhang R, Zhou Q Q, Yu H W, Guo H, Zheng W K, Liu X Q, Xu J, Deng X X, Xu Q, Luo J*. A metabolomics study in citrus provides insight into bioactive phenylpropanoid metabolism. Horticulture Research, 2023 Dec 19;11(1): uhad267.

9. Shen S Q#, Wang S C #, Yang C K, Wang C, Zhou Q Q, Zhou S, Zhang R, Li Y F, Wang ZX, Dai L P, Peng W J, Hao Y C, Guo H, Cao G P, Liu X Q, Yao F, Xu Q, Fernie Alisdair R, Luo J *. Elucidation of the melitidin biosynthesis pathway in pummelo. Journal of Integrative Plant Biology, 2023 Nov;65(11):2505-2518.

10. Hao Y C#, Xiang L J#, Lai J, Li C, Zhong Y, Ye W Z, Yang J, Yang J*, and Wang S C*. SlERF.H6 mediates the orchestration of ethylene and gibberellin signaling that suppresses bitter‐SGA biosynthesis in tomato. New Phytologist, 2023, doi: 10.1111/nph.19048

11. Guo H#, Cao P#, Wang C#, Lai J#, Deng Y#, Li C, Hao YC, Wu ZY, Chen RD, Qiang Q, Fernie Alisdair R., Yang J, Wang S*. Population analysis reveals the roles of DNA methylation in tomato domestication and metabolic diversity. Science China-Life Sciences, 2023, 66(8):1888-1902.

12. Zhao X C⁺, Zhang Y R⁺, Lai J, Deng Y, Hao Y C, Wang S C*, Yang J*. The SlDOG1 Affect Biosynthesis of Steroidal Glycoalkaloids by Regulating GAME Expression in Tomato. Int J Mol Sci, 2023, 24.

13. Zhang Z H⁺, Zhang F⁺, Deng Y, Sun L S, Mao M D, Chen R D, Qiang Q, Zhou J J, Long T, Zhao X C, Liu X Q, Wang S C, Yang J*, Luo J*. Integrated Metabolomics and Transcriptomics Analyses Reveal the Metabolic Differences and Molecular Basis of Nutritional Quality in Landraces and Cultivated Rice. Metabolites 2022, 12.

14. Wang S C ^+,*, Qiang Q⁺, Xiang L J, Fernie AR *, Yang J *.Targeted approaches to improve tomato fruit taste. Horticulture Research 2022.

15. Guo H⁺, Lai J⁺, Li C⁺, Zhou H H, Wang C, Ye W Z, Zhong Y, Zhao X C, Zhang F, Yang J *, Wang S C *. Comparative metabolomics reveals key determinants in the flavor and nutritional value of coconut by HS-SPME/GC-MS and UHPLC-MS/MS. Metabolites 2022, 12.

16. Zhao X C#, Zhang Y R#, Long T, Wang S C*, Yang J*. Regulation Mechanism of Plant Pigments Biosynthesis: Anthocyanins, Carotenoids, and Betalains. Metabolites 2022, Sep 16;12(9):871.

17. Wang S C⁺, Li Y⁺, He L Q⁺, Yang J, Fernie AR, Luo J. Natural variance at the interface of plant primary and specialized metabolism. Curr Opin Plant Biol 2022, 67:102201.

18. Wang S#, *, Xiao Y#, Zhou Z#, Wang X*, Chen L* & Luo J*. Cocos nucifera (coconut). Trends Genetics. 2022 Oct;38(10):1096-1097.

19. Wang, S#, Xiao, Y#, Zhou, Z#, Yuan, J#, Guo, H#, Yang, Z, Yang, J, Sun, P, Sun, L, Deng, Y, Xie, W, Song, J, Qamar, M, Xia, W, Liu, R, Gong, S, Wang, Y, Wang, F, Liu, X, Fernie, A, Wang, X*, Fan, H*, Chen, L* and Luo, J*. High-quality reference genome sequences of two coconut cultivars provide insights into evolution of monocot chromosomes and differentiation of fiber content and plant height. Genome Biology, 2021, 22, 304.

20. Yang J⁺, Chang Y⁺, Qin Y H, Chen D J, Zhu T, Peng K Q, Wang H J, Tang N, Li X K, Wang Y S, Liu Y M, Li X H, Xie W B, Xiong L Z. A lamin-like protein OsNMCP1 regulates drought resistance and root growth through chromatin accessibility modulation by interacting with a chromatin remodeler OsSWI3C in rice. New Phytol, 2020, 227, 65-83.

21. Zong W⁺, Yang J⁺, Fu J, Xiong L Z. Synergistic regulation of drought-responsive genes by transcription factor OsbZIP23 and histone modification in rice. J Integr Plant Biol, 2019, 62(6):723-729.

22. Fang C, Luo J, Wang S*, The Diversity of Nutritional Metabolites: Origin, Dissection, and Application in Crop Breeding. Front Plant Sci 2019, 10(1028):1028.

23. Ying S#, Su M#, Fu R, Li Y, Guo H, Luo J, Wang S*, Zhang Y*. Trichome regulator SlMX1 directly manipulates primary metabolism in tomato fruit. Plant Biotechnol J, 2019, 18, 354-363.

24. Wang S, Yang C, Tu H, Zhou J, Liu X, Cheng Y, Luo J, Deng X, Zhang H* & Xu J*. Characterization and metabolic diversity of flavonoids in citrus species. Sci Rep. 2017 Sep 5;7(1):10549.

25. Wang S, Tu H, Wan J, Chen W, Liu X, Luo J, Xu J*, Zhang H*. Spatio-temporal distribution and natural variation of metabolites in citrus fruits. Food Chem, 2016, 199, 8-17.

(二）授权专利

(1) 王守创; 杨君; 郭昊; 毛梦迪; 曹鹏; 邓渊; 陈日东; 赖军; 张越冉 ; 番茄SlERF063基因在促进果实成熟和降低果实毒性中的应用, 2024-1-30, 中国, ZL 2021 1 1584406.5

(2) 王守创; 赵学成; 张越冉; 杨君 ; 转录因子SlDOG1在提高植物甾体生物碱含量中的应用, 2023-7-7,中国, ZL 2022 1 1456348.2

(3) 王守创; 郝英辰; 向丽君; 杨君; 赖军; 李淳; 钟越; 叶炜桢 ; SlGA2ox基因在调节番茄有毒生物碱含量上的应用, 2024-2-20, 中国, ZL 2022 1 1598801.3

(4) 王守创; 郝英辰; 向丽君; 杨君 ; 番茄SlERF.H6基因在调控茄碱代谢降低番茄毒性中的应用, 2024-3-8, 中国, ZL 2022 1 1601055.9

(5) 王守创; 张凤; 杨君; 陈伟 ; 一种来自水稻的OsMYB44基因及其应用, 2024-3-8, 中国, ZL 2023 10014197.3

(6) 王守创; 张凤; 杨君; 陈伟 ; 一种来自水稻的OsUVR8基因及其应用, 2024-3-8, 中国, ZL 2023 10012979.3

(7) 罗杰; 王守创; 杨君; 郭昊; 刘贤青; 龙湍; 孙丽松 ; 一种用于鉴定椰子高矮品种的SNP位点及应用,2022-04-15, 中国, CN202110607720.4

(8) 熊立仲; 杨君; 覃永华 ; OsNMCP1基因在控制水稻耐旱中的应用, 2021-2-12, 中国, ZL2018 101860720.3

(9) 钱前; 郑晓明; 杨君; 彭友林; 乔继月; 吴比; 周萌萌; 王学强; 郑韶爵 ; 野生稻用集种装置,2023-12-22, 中国, ZL 2023 2 3046501.7